Research

BI Research Initiatives

The BI supports numerous McMaster researchers and external clients by providing a space for collaboration and discovery. Here we highlight a few core research areas and highlight publications that were supported by the BI team and equipment. We also provide more information on our Directors, their research initiatives, and other McMaster faculty members, who’s research has been accelerated by the BI facility.

Research Areas

Point-of-Care Diagnostics Diagnostic Suite

Point-of-care (POC) diagnostic tests, performed near a patient or at home, aim to provide rapid results, improve patient outcomes and lower healthcare costs. Similar to a home pregnancy or COVID testing device, POC tests developed at the BI use protein-targeting elements, known as DNAzymes.

Bioprocessing Bioprocess Automation Lab

A state-of-the-art biomanufacturing lab space will contribute to the development of biotherapeutics and improved access to life-saving treatments for chronic diseases. Thanks to a longstanding partnership with Sartorius, this 1,600 sq. ft. area, will serve as a training and development hub to investigate bioprocess modelling, simulation and advanced control.

Cell Biology BI Biological Suite

Many research groups operate within the BI Biological Preparation Suite to investigate biological behaviour and signaling. The mammalian culture laboratory supports research in cell signalling, cellular behaviour, and cellular responses to materials or toxins. In parallel, the bacterial culture laboratory complements this work by supporting the validation of diagnostic test strips as well as the development and assessment of antibacterial materials and solutions.

Environmental Analytes Test Strips View Publication

One of the first projects undertaken at the Biointerfaces Institute was the development of test strips for detection of environmental analytes (e.g. pesticides, heavy metals and E. coli), with practical applications in monitoring environmental and food-based toxins to support agriculture and food safety.

Publications

Below are a few impactful research publications, whereby the work was supported by the BI facility’s team and equipment. It would be impossible to highlight all the active research, as for over 12 years, the BI has supported numerous students, research fellows and faculty within the McMaster community. If you’d like to know more about the research, click on the panel to lead to the publication. If you’d like to have your recent publication highlighted, please contact us!

BI Directors

The BI facility is led by Dr. John Brennan and Dr. David Latulippe, who bring expertise in Chemistry & Chemical Biology and Chemical Engineering, respectively. Together, they guide BI initiatives to support a multidisciplinary research environment and promote collaboration across McMaster faculties, while ensuring high-quality analytical services are available to all our researchers and clients. Dr. Brennan’s current work investigates point-of-care diagnosics, while Dr. Latulippe is heavily optimizing bioprocess engineering workflows.

John Brennan Close Up

John Brennan

Biointerfaces Institute Co-Director

Professor, Chemistry & Chemical Biology

David Latullipe

David Latulippe

Biointerfaces Institute Co-Director

Associate Professor, Chemical Engineering

Meet our Members

The BI has supported the research initiatives of many faculty members at McMaster. For more details on our faculty members, click a profile link to see a summary of their research areas and gather more information by clicking on their “McMaster Experts Profile” link.