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Cell Disruptor (Constant Systems)

Biosafety Level 1 - Biological Preparation


Cell disruption uses high, constant pressures to compress cell samples, and accelerate them through a small fixed orifice at high velocity, in order to selectively break the cell wall and expose intracellular components. The bench-top TS-2 0.75kW model from Constant Systems is capable of pressures up to 40 kpsi resulting in approximately 10 mL stroke capacity with a 40 mL/min maximum flowrate. The disruption chamber is cooled with an external chiller (set to 4°C) to maintain sample integrity. The continuous sample run mode and electronic touch screen user interface allow for fast and easy sample disruption. Appropriate cell concentrations are recommended (eg. 25 g/L cell dry weight or 250 g/L cell wet weight).

Instrument Uses

  • Cell disruption of BSL-1 material only


  • McMaster Biosafety Training – See the BI Access &Training page for more information.
  • McMaster Biosafety Office approval of biological work is required
  • Biointerfaces Institute internal approval of biological work is required